3111T/C CLOCKGENE POLYMORPHISM IS NOT ASSOCIATED WITH SLEEP DISTURBANCES IN UNTREATED DEPRESSED PATIENTS

A sample of 100 patients with major depressive disorder showed no significant differences in sleep disturbances associated with the T3111C CLOCK variant.

• The study evaluated insomnia, daytime sleepiness, sleep quality, and depression severity.
• No significant associations were found between the T3111C CLOCK variant and depression severity as measured by the Hamilton Rating Scale.
• Genotype and allele groups did not show differences in comorbidity or chronotype distribution.
• Scores on the Epworth Sleepiness Scale, Athens Insomnia Scale, and Pittsburgh Sleep Quality Index were similar across genotypes.
• Findings did not support the hypothesis that the T3111C CLOCK variant influences sleep disturbances in patients with major depressive disorder.

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