Genes

Genetic Differences and Sex Influence How Childhood Trauma Affects Brain Wiring in Bipolar Disorder

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated

Abstract

Bipolar disorder is associated with circadian rhythm disruptions that may contribute to mood instability.

  • Circadian rhythms are regulated by clock genes in the suprachiasmatic nucleus.
  • The CLOCK 3111T/C (rs1801260) polymorphism is linked to delayed sleep phase and insomnia.
  • Circadian disruption and adverse childhood experiences correlate with white matter abnormalities.
  • It is hypothesized that rs1801260 may moderate the effects of adverse childhood experiences on white matter microstructure in bipolar disorder.

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