Clock-modulated checkpoints in time-restricted eating

Nov 21, 2021Trends in molecular medicine

Body Clock-Controlled Checkpoints in Time-Limited Eating

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Abstract

Time-restricted eating (TRE) limits daily meals to a window of 6-12 hours and may reduce cardiometabolic disease risks.

  • TRE consolidates circadian rhythms of metabolism and physiology.
  • Canonical circadian clocks are not necessary for TRE's effects in the liver.
  • Meal timing influences circadian rhythms in different tissues in a tissue-specific manner.
  • The liver and fat tissue respond readily to meal timing, while the heart and kidneys show resistance.
  • Identifying clock-modulated checkpoints (CCPs) could clarify how tissues respond to TRE.

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