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Clocking Cancer Immunotherapy Responses
Timing of Responses to Cancer Immunotherapy
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Abstract
Responses to immunotherapy in mice peak at the end of the resting phase (evening).
- Circadian rhythms influence T-cell movement through blood vessel linings.
- The time of day affects the expression of PD-L1 on myeloid immune cells.
- Tumor immunity, including dendritic cell activity, displays circadian patterns.
- Similar circadian effects are observed in patients undergoing cancer immunotherapy.
- Time-of-day may be an important factor in the effectiveness of cancer treatments.
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