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Abstract
The systematic examination of combinatorial chemistry approaches could enhance the synthesis of ionizable lipid libraries for high-throughput screening of lipid nanoparticles (LNPs).
- LNP-based gene therapy is seen as a transformative approach in modern medicine.
- Combinatorial chemistry may facilitate rapid synthesis and screening of ionizable lipids.
- Surface modification of LNPs with targeting ligands can be achieved through click and bioorthogonal chemistry.
- Advancements in barcoding technologies allow for thorough evaluation of LNP performance in both laboratory and living systems.
- Key design considerations and challenges exist in developing LNPs for effective mRNA delivery.
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