Comparison of morning vs bedtime administration of the combination of valsartan/amlodipine on nocturnal brachial and central blood pressure in patients with hypertension

The difference in nocturnal central systolic blood pressure between morning and bedtime administration of valsartan/amlodipine was -4.0 mm Hg.

• Nocturnal brachial systolic blood pressure was reduced by -3.2 mm Hg when comparing morning to bedtime administration.
• The 95% confidence interval for nocturnal brachial systolic BP ranged from -6.8 to 0.4 mm Hg.
• The reduction in nocturnal central systolic blood pressure had a 95% confidence interval of -7.6 to -0.4 mm Hg.
• Both morning and bedtime administrations were confirmed to be noninferior to each other for managing blood pressure during the night.

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