How Taking Valsartan/Amlodipine in the Morning or at Bedtime Affects Nighttime Arm and Central Blood Pressure in People with High Blood Pressure

The difference in nocturnal central systolic blood pressure between morning and bedtime administration of valsartan/amlodipine was -4.0 mm Hg.

• Nocturnal brachial systolic blood pressure was reduced by -3.2 mm Hg when comparing morning to bedtime administration.
• The 95% confidence interval for nocturnal brachial systolic BP ranged from -6.8 to 0.4 mm Hg.
• The reduction in nocturnal central systolic blood pressure had a 95% confidence interval of -7.6 to -0.4 mm Hg.
• Both morning and bedtime administrations were confirmed to be noninferior to each other for managing blood pressure during the night.

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