The Bedtime Administration Ameliorates Blood Pressure Variability and Reduces Urinary Albumin Excretion in Amlodipine-Olmesartan Combination Therapy

Bedtime administration of amlodipine-olmesartan reduced morning blood pressure surge by 24.2 ± 13.5 mmHg compared to 32.3 ± 14.2 mmHg in the morning.

• Bedtime dosing significantly decreased morning blood pressure surge with a p-value of < 0.001.
• In patients who do not dip at night, bedtime administration improved nocturnal blood pressure patterns.
• Nocturnal blood pressure did not decrease in patients who experience dipping.
• The urinary albumin-to-creatinine ratio was lower with bedtime dosing at 42.5 ± 59.9 mg/g compared to 75.3 ± 26.4 mg/g in the morning with a p-value of 0.044.
• These findings suggest that bedtime dosing may better achieve therapeutic goals in managing hypertension.

AI simplified