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Control of immunity and allergy by steroid hormones
How steroid hormones influence the immune system and allergies
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Abstract
Steroid hormones, particularly glucocorticoids, androgens, and estrogens, have significant effects on immune responses.
- Glucocorticoids are associated with strong anti-inflammatory and immunosuppressive effects on innate immunity.
- They suppress the production of inflammatory cytokines by macrophages and dendritic cells.
- Glucocorticoids enhance adaptive immunity by increasing IL-7R and CXCR4 expression in T cells.
- Androgens are linked to the suppression of ILC2 homeostasis, Th2 and Th17 cell activation, and enhancement of Treg function.
- These findings indicate that steroid hormones play diverse roles in regulating the immune system.
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