Allergology international : official journal of the Japanese Society of Allergology

How steroid hormones influence the immune system and allergies

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Steroid hormones, particularly glucocorticoids, androgens, and estrogens, have significant effects on immune responses.

  • Glucocorticoids are associated with strong anti-inflammatory and immunosuppressive effects on innate immunity.
  • They suppress the production of inflammatory cytokines by macrophages and dendritic cells.
  • Glucocorticoids enhance adaptive immunity by increasing IL-7R and CXCR4 expression in T cells.
  • Androgens are linked to the suppression of ILC2 homeostasis, Th2 and Th17 cell activation, and enhancement of Treg function.
  • These findings indicate that steroid hormones play diverse roles in regulating the immune system.

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