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Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4
Daily Hormone Cycles Influence T Cell Movement and Activity by Increasing Key Receptors
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Abstract
Glucocorticoid receptor signaling induces IL-7R expression in mouse T cells with a peak at midnight.
- Glucocorticoids may regulate T cell homeostasis and responses at physiological concentrations.
- The diurnal pattern of IL-7R expression supports T cell survival and affects their movement between lymph nodes, spleen, and blood.
- Increased T cell accumulation in the spleen at night may enhance immune responses to soluble antigens and bacterial infections.
- The findings suggest a role for glucocorticoids in regulating immune function according to the body's daily rhythm.
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