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Abstract
The CRISPR-Cas9 genome-editing system offers transformative strategies for reprogramming immune responses.
- Dysregulated immune activity is linked to both cancer progression and autoimmune diseases.
- Conventional immunotherapy methods often face limitations in precision, efficacy, and long-term safety.
- The CRISPR-Cas9 toolkit includes techniques such as gene knock out, knock in, transcriptional activation, and base editing.
- These strategies can enhance anti-tumor immunity by modifying immune cells to overcome inhibitory checkpoints.
- CRISPR technology may help restore immune tolerance, addressing issues of autoimmunity through precise genomic interventions.
- Future advancements could focus on next-generation editors and improved delivery systems to enhance therapeutic outcomes.
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