The Effect of Curcumin on Ethanol Induced Changes in Suprachiasmatic Nucleus (SCN) and Pineal

Sep 12, 2007Cellular and molecular neurobiology

Curcumin's effect on alcohol-related changes in the brain's biological clock and hormone gland

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Ethanol withdrawal could not restore rhythmicity or levels of serotonin and its metabolite in the suprachiasmatic nucleus and pineal gland.

  • Circadian clocks are localized in the suprachiasmatic nucleus (SCN) of mammals, regulating melatonin production from the pineal gland.
  • Alcoholism is associated with various clock-linked neuronal disorders, including memory loss, sleep disorders, and dementia.
  • Serotonin plays a significant role in mediating the effects of alcohol on the brain.
  • Ethanol drinking and withdrawal were studied for their effects on daily rhythms of serotonin and its metabolite, 5-hydroxy-indole acetic acid (5-HIAA), in adult male Wistar rats.
  • Curcumin partially restored the daily serotonin/5-HIAA ratio and caused phase shifts in the SCN and pineal gland.

AI simplified

Full Text

Full text is available at the source.
View full text (PDF) ↗View full text (HTML) ↗View full text ↗

Related papers

Nov '22
Daytime-limited feeding differently affects age-related changes in serotonin processing in the brain's biological clock and the pineal gland of male rats
top 20% journal
cited by 6 papers
research support, non-u.s. gov't
Dec '14
Melatonin affects daily serotonin metabolism changes with aging in the brain’s internal clock of male rats
top 20% journal
cited by 24 papers
comparative study
Jun '04
Communication from the brain’s daily rhythm center to the pineal gland during light and dark: changes in key signaling molecules after melatonin injection
top 20% journal
cited by 16 papers
research support, non-u.s. gov't
Nov '04
Midday darkness and its effects on daily rhythm genes in the rat’s internal clock and melatonin-making gland
cited by 9 papers
comparative study
Nov '14
Daily patterns of serotonin and body clock genes in the brain's time-keeping center in a Parkinson’s rat model and how melatonin may affect them
top 20% journal
cited by 56 papers
research support, non-u.s. gov't
Jan '93
Melatonin, the brain’s night-time hormone gland, and body clocks
top 20% journal
research support, u.s. gov't, non-p.h.s.

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief