Pakistan journal of pharmaceutical sciencesJul 11, 2026

Curcumin’s potential to affect the GLP-1 pathway through TGR5 in type 2 diabetes with obesity

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Jul 14, 2026

Abstract

Enhancing endogenous GLP-1 signaling may provide clinical value in managing type 2 diabetes mellitus with obesity.

Glycemic control and weight reduction are both necessary for effective management of type 2 diabetes in obese patients.
TGR5 is identified as an important target for enhancing GLP-1 signaling.
The curcumin family has gained interest for its potential effects on this signaling pathway.
Current mechanistic evidence regarding the role of curcumin in this context is limited and scattered.

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