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Dark adaptation-induced changes in rod, cone and intrinsically photosensitive retinal ganglion cell (ipRGC) sensitivity differentially affect the pupil light response (PLR)
How dark adaptation changes sensitivity in rod, cone, and light-sensitive eye cells differently affect pupil responses to light
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Abstract
The transient contraction amplitude of the pupil light response increased significantly by up to 45.1% during the initial phase of dark adaptation.
- The sustained contraction amplitude and relative sustained contraction ratio changed by up to 71.0% and 37.2%, respectively, during the first 20 minutes of dark adaptation under high-intensity blue light.
- An inflection point in the contraction curves was observed at 15 or 20 minutes of dark adaptation.
- Similar patterns of changes in pupil light response were noted in patients with neural or retinal vision loss.
- Different photoreceptors showed varying rates of sensitivity changes during the dark adaptation process.
- A 20-minute dark adaptation period is suggested for achieving a consistent pupil response during testing.
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