The post‐illumination pupil response of melanopsin‐expressing intrinsically photosensitive retinal ganglion cells in diabetes

Patients with Type II diabetes exhibited a trend of reduced ipRGC function, with lower average pupil constriction in response to blue light compared to healthy controls.

• The blue post-illumination pupil response (PIPR) was measured in seven patients with Type II diabetes without diabetic retinopathy.
• A linear relationship was observed between the duration of diabetes and the amplitude of the blue PIPR, indicating that ipRGC function may decline with longer diabetes duration.
• The results suggest that ipRGC-controlled PIPR could serve as a non-invasive technique for assessing inner retinal changes in diabetic patients.
• Lower transient pupil constriction amplitudes in the diabetic group may indicate potential impacts on outer retinal photoreceptor inputs.

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