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Daytime restricted feeding promotes circadian desynchrony and metabolic disruption with changes in bile acids profiles and gut microbiota in C57BL/6 Male Mice
Daytime-Only Feeding May Disrupt Body Clocks and Metabolism by Changing Bile Acids and Gut Bacteria in Male Mice
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Abstract
Daytime feeding in mice resulted in significant alterations in liver gene expression and gut microbiota composition.
- Hepatic rhythmic expressions of key clock genes and lipid metabolism genes were disrupted by daytime feeding.
- Daytime feeding led to an increase in levels of primary, secondary, and unconjugated bile acids at ZT0, but decreased them at ZT12.
- The diversity of gut microbiota was altered, showing an increase in Firmicutes and a decrease in Verrucomicrobia.
- Fluctuations in specific gut bacteria, including Akkermansia, Lactobacillus, and Parabacteroides, were observed under daytime feeding conditions.
- Shifting food intake to the rest phase is associated with desynchronization between circadian rhythms and metabolic processes in the liver.
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