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Abstract
Metabolomics may improve the accuracy of aging clocks by capturing real-time physiological status.
- Current epigenetic clocks have limitations in tracking dynamic metabolic changes and specific aging patterns.
- Metabolomics represents the culmination of various biological processes that reflect physiological conditions.
- A proposed three-phase causal strategy includes global screening, local verification, and dynamic validation.
- The integrated methodology aims to enhance both the predictive accuracy and biological relevance of aging biomarkers.
- Evaluating metabolomic aging clocks may provide insights for extending human healthspan and improving strategies for age-related diseases.
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