Full text is available at the source.
Deoxynivalenol may cause liver damage by blocking protective cell signals through excessive removal of damaged mitochondria
Updated
Abstract
Deoxynivalenol (DON) induces liver injury by overactivating mitophagy and inhibiting the p62-Keap1-Nrf2 signaling pathway.
- DON treatment in mice and hepatocyte cells leads to mitochondrial damage.
- Overactivation of PINK1/Parkin-mediated mitophagy is observed with DON exposure.
- This mitophagy overactivation is associated with increased apoptosis, oxidative stress, inflammation, and lipid metabolism disorders.
- DON suppresses the p62-Keap1-Nrf2 cytoprotective pathway, weakening cellular defenses.
- Overexpression of p62 can reduce liver injury caused by DON by promoting Nrf2 activity.
Simplified