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Desflurane and sevoflurane reduce contractions in pregnant rat uterus stimulated by oxytocin
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Abstract
Oxytocin increased the duration and amplitude of contractions significantly, while 2 MAC of desflurane and sevoflurane inhibited these effects.
- Oxytocin caused a significant increase in the amplitude and duration of uterine contractions without affecting their frequency.
- At 2 MAC, desflurane inhibited contraction duration by 84% and amplitude by 90%.
- Sevoflurane inhibited contraction duration by 79% and amplitude by 84% at the same dosage.
- Both anesthetics exhibited a dose-dependent inhibition on oxytocin-induced contractions in isolated rat myometrium.
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