Inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated pregnant human myometrium

Sep 9, 2005Acta anaesthesiologica Scandinavica

Desflurane and sevoflurane reduce oxytocin-triggered contractions in isolated pregnant uterine muscle

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Desflurane and sevoflurane significantly reduce the frequency and amplitude of oxytocin-induced contractions in isolated human myometrium at doses of 0.5, 1, and 2 minimum alveolar concentration (MAC).

After oxytocin administration, the frequency and amplitude of contractions increased, while the duration decreased.
Both desflurane and sevoflurane significantly decreased the frequency and amplitude of contractions compared to controls.
At 1 MAC, the amplitude of contractions was significantly different between desflurane and sevoflurane.
The duration of contractions decreased at 2 MAC in both desflurane and sevoflurane groups.

AI simplified

BACKGROUND: In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated human myometrium.

METHODS: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (n = 10), were obtained from 20 non-laboring term parturients. The study protocol consisted of a 60-min period of spontaneous contractions, control recording with oxytocin 2 x 10(9) m (10-min period), washout interval of 10 min, volatile administration (three times per 15-min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10-min period), a further washout interval (10-min period) and subsequent control recording with oxytocin without anesthetics.

RESULTS: After oxytocin administration, the frequency and amplitude of contractions increased (P < 0.05) and the duration decreased (P < 0.05). The frequency and amplitude of contractions induced with oxytocin decreased significantly at 0.5, 1 and 2 MAC of desflurane and sevoflurane (P < 0.05). The amplitude of contractions was significantly different at 1 MAC between the two groups (P < 0.05). The duration of contractions at 2 MAC decreased in both groups (P < 0.05).

CONCLUSIONS: Desflurane and sevoflurane at 0.5, 1 and 2 MAC inhibit the frequency and amplitude of myometrial contractions induced with oxytocin in a dose-dependent manner. However, desflurane inhibits the amplitude less than sevoflurane at 1 MAC. We suggest that 0.5 MAC of both agents and 1 MAC of desflurane may be safely used in the presence of oxytocin following delivery of the infant and placenta during Cesarean section without fear of uterine atony and hemorrhage.

Full Text

Full text is available at the source.

View full text ↗

Inhibitory effects of desflurane and sevoflurane on oxytocin‐induced contractions of isolated pregnant human myometrium

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief