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Comparing the relaxing effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated myometrium in both pregnant and nonpregnant rats
Comparing the relaxing effects of two anesthetics on hormone-induced uterine muscle contractions in pregnant and nonpregnant rats
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Abstract
Oxytocin significantly increased the amplitude and duration of contractions in isolated myometrium from pregnant rats.
- Oxytocin was shown to enhance contraction strength and length in longitudinal myometrial strips but did not affect how often contractions occurred.
- Desflurane and sevoflurane both reduced the strength, length, and frequency of contractions in a dose-dependent manner, except for the lowest dose in nonpregnant rats.
- The sensitivity to the inhibitory effects of desflurane and sevoflurane was greater in myometrium from pregnant rats compared to nonpregnant rats.
- The inhibitory effects of desflurane and sevoflurane were found to be similar in their potency.
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