Nature reviews. Endocrinology

How diabetes harms the kidneys and current and new treatments

Updated

Abstract

Sodium-glucose cotransporter 2 inhibitors may slow chronic kidney disease progression and improve cardiovascular outcomes in diabetic kidney disease.

  • Diabetic kidney disease often presents with reduced kidney function and protein in the urine.
  • Strict management of blood sugar and blood pressure is essential for controlling diabetic kidney disease.
  • Glucagon-like peptide 1 receptor agonists are associated with reduced protein in the urine and better preservation of kidney function.
  • Finerenone has been shown to lower risks related to kidney and heart health in patients with diabetic kidney disease.
  • Combination therapies, including sodium-glucose cotransporter 2 inhibitors and other targeted treatments, may enhance treatment efficacy.
  • Key drivers of diabetic kidney disease include increased kidney pressure, damage to kidney cells, and inflammation.

Simplified

Full Text

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Funding

Competing interests

Competing interests: The authors declare no competing interests.
PubMed

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