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Abstract
Dysbiosis is increasingly associated with neurological, psychiatric, and neurodevelopmental disorders, including Alzheimer's disease and depression.
- The gut microbiota influences host health through the microbiota-gut-brain axis, impacting immune, metabolic, and neuroendocrine functions.
- Diet significantly shapes the gut microbiota, affecting microbial composition and the production of neuroactive compounds.
- Experimental studies suggest mechanisms linking gut microbiota to brain function, such as immune system modulation and signaling through the vagus nerve.
- Human studies face challenges due to genetic diversity, dietary differences, medication effects, and other lifestyle factors.
- Microbiota-targeted interventions like precision nutrition and probiotics show potential but also have current limitations.
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