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Dietary fiber modulates gut microbiota and lipid metabolism ameliorating Alzheimer’s pathology in 5xFAD mice
Dietary fiber changes gut bacteria and fat metabolism, improving Alzheimer's symptoms in mice
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Abstract
Dietary fiber supplementation in 5xFAD mice led to significant reductions in deposition and improved cognitive performance.
- Fiber-plus diets resulted in notable changes in composition, increasing beneficial bacteria while decreasing harmful types.
- Significant shifts in fecal lipid metabolites were observed, including alterations in phospholipids and long-chain fatty acids.
- FP-fed AD mice showed reduced activation of immune cells in the brain and better brain cell structure.
- Enhanced neurogenesis in the hippocampus was noted, along with preservation of proteins essential for synaptic function.
- Increased intestinal permeability seen in AD mice was mitigated with fiber-plus supplementation.
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Key numbers
12 of 12 mice
Increase in cognitive performance
In the novel object recognition test, FPAD mice preferred novel objects.
/ ratio significantly decreased
Decrease in / ratio
analysis showed reduced Aβ levels in FPAD mice.
FITC-dextran levels significantly decreased
Reduction in gut permeability
FPAD mice exhibited reduced FITC-dextran concentrations in serum.