Food research international (Ottawa, Ont.)Nov 11, 2025

Red wine polyphenols lower amyloid-beta buildup in Alzheimer's mice, possibly involving gut-brain interactions

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 1, 2026

Abstract

Dealcoholized red wine (DRW) reduced Aβ40 and Aβ42 levels in APP/PS1 mice, with males showing greater sensitivity.

DRW may influence amyloid levels associated with Alzheimer's disease pathology.
Fecal metabolomics indicated that DRW modulates sex-specific metabolic pathways.
In males, DRW affected lipid and mitochondrial pathways, while in females, it influenced broader metabolic networks.
Guanosine and estradiol phenylpropionate levels correlated with Aβ42 in females, suggesting potential sex-specific mechanisms.
The effects of RW components on AD pathology may depend on dosage and sex.

Simplified

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder influenced by genetics and lifestyle. The Mediterranean diet, especially moderate red wine (RW) intake, may offer neuroprotection through (poly)phenols acting on amyloid pathology, neuroinflammation, and the gut-brain axis. This study evaluated RW and dealcoholized red wine (DRW) effects on hippocampal Aβ in APP/PS1 mice. DRW reduced Aβ40 and Aβ42, levels, with males showing greater sensitivity. Untargeted fecal metabolomics revealed DRW modulates sex-specific metabolic pathways. In males, enriched lipid and mitochondrial pathways were observed, while in females, DRW impacted broader networks, including nucleotide, TCA cycle, and hormone metabolism. Guanosine and estradiol phenylpropionate correlated with Aβ42 in females, indicating sex-specific mechanisms. Findings suggest RW components may attenuates AD pathology via amyloid reduction and metabolic modulation, being dose and sex dependent. This highlights the potential of gut-derived metabolites in mediating (poly)phenol-driven neuroprotection and the importance of personalized dietary approaches to AD.

Full Text

Full text is available at the source.

View Full Text ↗

Funding

Competing interests

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

PubMed

Red wine polyphenols lower amyloid-beta buildup in Alzheimer's mice, possibly involving gut-brain interactions

Abstract

Full Text

Funding

Competing interests

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the gut-brain axis brief

Abstract

Full Text

Funding

Competing interests

Related papers

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the gut-brain axis brief