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Red wine (poly)phenols supplementation reduces amyloid-beta (aβ) pathology in APP/PS1 mice model: Possible implications of gut-brain axis explored by untargeted fecal metabolomics
Red wine polyphenols lower amyloid-beta buildup in Alzheimer's mice, possibly involving gut-brain interactions
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Abstract
Dealcoholized red wine (DRW) reduced Aβ40 and Aβ42 levels in APP/PS1 mice, with males showing greater sensitivity.
- DRW may influence amyloid levels associated with Alzheimer's disease pathology.
- Fecal metabolomics indicated that DRW modulates sex-specific metabolic pathways.
- In males, DRW affected lipid and mitochondrial pathways, while in females, it influenced broader metabolic networks.
- Guanosine and estradiol phenylpropionate levels correlated with Aβ42 in females, suggesting potential sex-specific mechanisms.
- The effects of RW components on AD pathology may depend on dosage and sex.
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