Poor sleep patterns were associated with higher odds of liver fibrosis (OR = 3.23).
intake of ≥ 15 gm/day was linked to a lower risk of liver fibrosis (OR = 0.51).
In individuals with dietary fiber intake < 15 gm/day, poor sleep patterns significantly increased the risk of liver fibrosis (OR = 15.13).
No association was found between poor sleep patterns and liver fibrosis in patients with higher dietary fiber intake.
Moderate dietary fiber supplementation may help mitigate the impact of poor sleep patterns on liver fibrosis.
Simplified
BACKGROUND: Insufficient nocturnal sleep was associated with a higher risk of fibrosis in patients with (MASLD). intake may improve the stimulate the secretion of sleep cytokines, inhibit the inflammatory pathway, contribute to regulating sleep disorders and alleviate . The associations of dietary fiber intake, sleep patterns, with liver fibrosis remain unclear. The study aimed to explore the associations between dietary fiber, sleep, and liver fibrosis, as well as the moderating effect of dietary fiber intake between sleep patterns and liver fibrosis in MASLD patients.
METHODS: Using data from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2017 to 2020, a cross-sectional study included participants with MASLD was performed to assess the relationship between sleep patterns, dietary fiber intake, and liver fibrosis. Weighted univariate and multivariate logistic regression models were used to examine the linear connection between sleep pattern, dietary fiber intake, and liver fibrosis. Restricted cubic spline (RCS) method was also performed to describe the nonlinear relationship. A two-part linear regression model was also used to estimate threshold effects. The moderating effect of dietary fiber intake was further investigated in different subgroups. All results were presented as odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS: Totally, 1343 MASLD patients were included for final analysis. Among them, 207 (15.41%) have liver fibrosis. Dietary fiber intake did not correlate significantly with sleep pattern in patients with MASLD (Spearman's r = -0.028, P = 0.1678). Poor sleep pattern was related to higher odds of liver fibrosis (OR = 3.23, 95%CI: 1.05-9.90), while dietary fiber intake ≥ 15 gm/day was associated with lower liver fibrosis risk (OR = 0.51, 95%CI: 0.32-0.83). On the association between sleep pattern and liver fibrosis stratified by dietary fiber intake revealed that poor sleep patterns (OR = 15.13, 95%CI: 4.40-52.01) remained associated with increased liver fibrosis risk among individuals with dietary fiber intake < 15 gm/day. No connection was observed between poor sleep patterns and liver fibrosis in MASLD patients with higher dietary fiber intake, with moderate dietary fiber supplementation beneficial in mitigating poor sleep patterns associated with liver fibrosis. The similar findings were also found in patients aged < 50 years old, ≥ 50 years old, females, those with and without CVD groups, hypertension, and dyslipidemia. Particularly, dietary fiber intake also moderates the relationship between sleep patterns and liver fibrosis in the F4 stage (OR = 13.26, 95%CI: 4.08-43.11).
CONCLUSION: Dietary fiber intake affects the relationship between sleep patterns and liver fibrosis in MASLD patients.
Key numbers
3.23
Increased Odds of
Odds Ratio for poor sleep patterns in patients
0.51
Lower Odds of
Odds Ratio for intake ≥ 15 gm/day
15.13
Severe Increase in Risk
Odds Ratio for poor sleep patterns with intake < 15 gm/day
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Declarations. Ethics approval and consent to participate: The requirement of ethical approval for this was waived by the Institutional Review Board of Beijing Shunyi Hospital, because the data was accessed from NHANES (a publicly available database). The need for written informed consent was waived by the Institutional Review Board of Beijing Shunyi Hospital due to retrospective nature of the study. All methods were performed in accordance with the relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
