Associations between systemic inflammatory biomarkers and metabolic dysfunction associated steatotic liver disease: a cross-sectional study of NHANES 2017–2020

Jan 29, 2025BMC gastroenterology

Links between blood inflammation markers and metabolism-related fatty liver disease in US adults

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Abstract

Among 6613 adults, specific systemic inflammatory biomarkers are significantly associated with metabolic dysfunction-associated steatotic liver disease () risk.

  • and are negatively associated with MASLD risk, while , , and show a positive association.
  • Most biomarkers, including ALI, SIRI, IBI, CAR, LMR, and PNI, have significant non-linear correlations with MASLD.
  • Age-related differences significantly influence the association between ALI and MASLD risk.
  • Variations in the relationship between PNI and MASLD risk are observed across different cardiovascular outcomes.

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Key numbers

29.8–45.2%
Prevalence of
Estimated prevalence range of in the United States.
6613 adults
Study Population Size
Total number of adults assessed in the NHANES study.
34.67% aged 40-59 years
Age Group Proportion
Percentage of participants in the 40-59 age group.

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