Differential Targeting of Two Distinct SWI/SNF-Related Drosophila Chromatin-Remodeling Complexes

Drosophila contains two distinct subclasses of the SWI/SNF family of chromatin-remodeling complexes.

• Two novel proteins associated with the BRM complex in Drosophila, Polybromo and BAP170, were identified.
• The two subclasses of BRM complexes are defined as the BAP complex, which lacks Polybromo and BAP170, and the PBAP complex, which contains them.
• Genome-wide analysis showed that BAP and PBAP complexes have overlapping but distinct distribution patterns on larval salivary gland chromosomes.
• Both complexes are found predominantly in regions of open, hyperacetylated chromatin and are largely absent from repressive chromatin marked by Polycomb.
• These findings indicate that Drosophila exhibits a chromatin regulation mechanism similar to that of yeast and human cells.

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