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Dim light at night attenuates circadian rhythms in the cardiovascular system and suppresses melatonin in rats
Dim light at night weakens daily heart rhythms and reduces melatonin in rats
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Abstract
ALAN significantly suppressed the 24-h variability in heart rate, blood pressure, and spontaneous baroreflex sensitivity after 2 weeks.
- After 5 weeks of ALAN exposure, the parameters showed partial restoration of 24-h variability.
- The blood pressure response to norepinephrine was reduced after 2 weeks and restored after 5 weeks.
- ALAN increased the blood pressure response to norepinephrine compared to control levels after 5 weeks.
- Increased expression of endothelial nitric oxide synthase was observed in arteries after 2 weeks but not after 5 weeks.
- Plasma melatonin levels were suppressed after both 2 and 5 weeks of ALAN exposure.
- Spontaneous exploratory behavior was reduced during the study.
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