Daily Changes in Kidney Salt and Mineral Removal and the Role of Local Chemical Signals

Many physiological processes, including kidney functions, follow specific 24-hour rhythms.

• Circadian genes are present in nearly every cell type in the body.
• Noncanonical genes also exhibit intrinsic circadian rhythms, particularly in the liver and kidney.
• The regulation of renal electrolyte excretion may be influenced by circadian rhythms.
• Paracrine and autocrine factors, such as the endothelin system, may be regulated by clock genes.
• Electrolyte excretion is known to vary with the time of day, potentially affecting fluid balance and blood pressure.

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