American journal of physiology. Renal physiology

New Insights into How the Kidney’s Internal Clock Works

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Circadian rhythms regulate kidney function, influencing homeostasis and metabolic waste excretion.

  • The kidney's role in maintaining water and electrolyte balance is influenced by circadian rhythms.
  • Blood pressure regulation in the kidney also displays a pattern linked to the time of day.
  • Disrupted circadian rhythms may negatively impact kidney health.
  • Understanding molecular mechanisms of circadian regulation in the kidney has advanced significantly in the past decade.
  • Future research should consider the time of day as a critical variable in kidney studies.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Funding

Competing interests

Michelle L. Gumz is an editor of the American Journal of Physiology-Renal Physiology and was not involved and did not have access to information regarding the peer-review process or final disposition of this article. An alternate editor oversaw the peer-review and decision-making process for this article. None of the other authors has any conflicts of interest, financial or otherwise, to disclose.
PubMed

Related papers

Oct '24
Sex differences in the daily adrenal clock: BMAL1’s role in controlling urine aldosterone and kidney salt balance in mice
cited by 8 papers
journal article
Jan '18
Daily rhythms in kidney function
top 5% journal
cited by 80 papers
research support, n.i.h., extramural
Oct '19
Daily Changes in Kidney Salt and Mineral Removal and the Role of Local Chemical Signals
top 1% journal
cited by 21 papers
research support, n.i.h., extramural
Jun '19
Timing-based approaches to discovering new drugs
top 2% journal
cited by 52 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #49
Your body clock controls which drugs work — and a protein called gp78 is why
6 days ago7 studies
issue #48
A blood test can now estimate your internal clock time using just 60 proteins
1 week ago7 studies
issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
2 weeks ago7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
3 weeks ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
4 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
5 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
6 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
7 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
8 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief