Dose-response associations of the American Heart Association's new “Life's essential 8” metrics with all-cause and cardiovascular mortality in a nationally representative sample from the United States

The analysis of 23,531 adults suggests that optimal levels of the American Heart Association's LIFE's Essential 8 (LE8) score could reduce all-cause mortality by 40%.

• A significant inverse relationship was observed between the LE8 score and both all-cause and cardiovascular disease (CVD) mortality.
• The optimal risk reduction for all-cause mortality occurred at a LE8 score of 100 points, with a hazard ratio of 0.50.
• A similar significant association for CVD mortality was noted, with the optimal score at 90 points yielding a hazard ratio of 0.41.
• The study indicates that higher LE8 scores may correspond to a lower risk of death from all causes and CVD over a median follow-up of 7.3 years.

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