Life's Essential 8 and the risk of cardiovascular disease: a systematic review and meta-analysis

Aug 22, 2024European journal of preventive cardiology

The Life's Essential 8 health factors and their link to heart disease risk

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Among 1,786,664 participants, higher Life's Essential 8 (LE8) scores are associated with a 53% lower risk of cardiovascular disease (CVD).

Higher LE8 scores correlate with a significant decrease in CVD risk, indicated by a hazard ratio (HR) of 0.47.
An increase in LE8 scores is linked to a 46% reduction in all-cause mortality, with an HR of 0.54.
LE8 scores are associated with a 63% lower risk of CVD-related mortality, reflected in an HR of 0.37.
Individuals achieving higher LE8 scores exhibit a 56% lower risk of coronary heart disease.
A 48% lower risk of stroke is also observed in those with high LE8 scores.

AI simplified

AIMS: The benefits of achieving optimal cardiovascular health (CVH) through Life's Simple 7 (LS7) are well-documented across diverse populations. In this study, we assess the updated metrics, Life's Essential 8 (LE8), and its association with long-term cardiovascular disease (CVD) outcomes and mortality.

METHODS AND RESULTS: We conducted a comprehensive systematic review, searching PubMed, Google Scholar, Cochrane Library, and ScienceDirect from January 2022 until June 2024, focusing on studies that specifically assessed the impact of LE8 on CVH. The statistical analysis used RevMan 5.4 and applied a random effects model to synthesize hazard ratios (HRs) for primary and secondary outcomes. This study is registered in PROSPERO (CRD42024558493). Our final analysis comprised 34 observational studies, encompassing 1 786 664 participants aged 18-80 years, with an average follow-up of approximately 11.6 years. Pooled analysis revealed a statistically significant decrease in the risk of CVD among individuals with higher LE8 scores compared with those with lower scores, with an HR of 0.47 (95% CI: 0.39-0.56, P < 0.00001). Higher LE8 scores were also associated with significant reductions in both all-cause mortality (HR: 0.54, 95% CI: 0.43-0.69, P < 0.00001) and CVD-related mortality (HR: 0.37, 95% CI: 0.26-0.52, P < 0.00001. Moreover, individuals with high LE8 scores have a 56% lower risk of coronary heart disease and a 48% lower risk of stroke.

CONCLUSION: LE8 has a strong inverse association with CVD risk and mortality, with higher LE8 scores corresponding to significantly lower risk levels.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text ↗

Life's Essential 8 and the risk of cardiovascular disease: a systematic review and meta-analysis

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief