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Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY
Light-dependent interaction between Drosophila's light-sensing protein and its internal clock protein involving the tail end of the light sensor
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Abstract
Behavioral analysis of double mutants of per and cry indicates a genetic interaction between these two loci.
- Drosophila CRYPTOCHROME (CRY) shows a previously unreported physical interaction with PERIOD (PER).
- A yeast-two-hybrid system confirmed dimerization between CRY and PER.
- Coimmunoprecipitation assays in tissue culture cells further supported the interaction.
- The light-dependent interactions of PER and TIMELESS (TIM) with CRY require the C terminus of CRY.
- The findings suggest that CRY's role in light responses may extend beyond its interactions with TIM.
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