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On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus
How two internal clocks in the brain's daily rhythm center may have started and changed over time
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Abstract
Colin Pittendrigh's model of a circadian clock, involving two coupled oscillators, remains influential decades after its proposal.
- The model suggests oscillators that respond to the rising and setting sun to adapt behaviors and physiological processes to seasonal changes.
- Research has focused on identifying these evening and morning oscillators in various species, including insects, rodents, and humans.
- Technological advancements in biology and neuroscience have enhanced experimental designs aimed at studying these oscillators.
- The dual oscillator model continues to shape our understanding of the circadian clock located in the mammalian suprachiasmatic nucleus.
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