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The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm
The mammal body clock: a layered system of multiple internal timers that create daily rhythms
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Abstract
The circadian clock operates with a periodicity of approximately 24 h.
- The mammalian circadian system consists of a hierarchical structure with a central clock in the suprachiasmatic nucleus (SCN) and peripheral clocks throughout the body.
- Key clock genes in mammals are involved in complex feedback loops that regulate the circadian rhythm.
- Each cell has its own independent clock, but cells in the SCN are coupled to form regional oscillators that synchronize to create a unified tissue rhythm.
- The coupling between regional oscillators is important for the stability and adaptability of the circadian clock.
- New molecular tools are aiding in the understanding of the mechanisms behind the circadian clock's function.
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