Journal of agricultural and food chemistryOct 23, 2024

Changing Water Content and Thickness of Konjac Glucomannan Helps Reduce Food Intake and Supports Long-Term Weight Loss in Mice on a High-Fat Diet

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 20, 2026

Abstract

KGM supplementation led to an 18.27% reduction in daily food intake over 10 weeks in mice on high-fat diets.

KGM supplementation reduced body and tissue weights in mice on high-fat diets.
The hydration rate and viscosity of KGM significantly influenced its antiobesity effects.
Medium hydration and viscosity of KGM slowed gastric emptying and intestinal transit.
Increased levels of satiety-related hormones (GLP-1 and PYY) were observed with effective KGM formulations.
KGM altered gene transcription related to glycolipid metabolism and enriched beneficial gut bacteria, though effects varied among KGM groups.

Simplified

The purpose of this study was to investigate the necessity and importance of dynamic hydration rate and ultimate viscosity control of konjac glucomannan (KGM) for long-term antiobesity effects in C57BL/6J mice on high-fat (HF) diets. KGM supplementation effectively attenuated HF-diet-induced increases in body and tissue weights. The hydration rate and viscosity changes of KGM in the digestive tract were found to have marked impacts on antiobesity effects. KGM with medium hydration and viscosity slowed gastric emptying and intestinal transit, leading to prolonged presence in the lower ileum, increased satiety-related hormones (GLP-1 and PYY), and an 18.27% reduction in daily food intake over 10 weeks (< 0.05). This resulted in the greatest reduction in weight gain among HF-fed mice. In contrast, KGM with faster hydration and higher viscosity provided only short-term satiety due to rapid dilution. Furthermore, KGM improved metabolic health and altered glycolipid metabolism gene transcription while enriching beneficial gut bacteria; however, no significant differences were observed among the KGM groups in these effects. These findings highlight that synchronizing KGM's hydration rate and viscosity with digestive processes is crucial for regulating satiety and achieving long-term weight loss. p

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Changing Water Content and Thickness of Konjac Glucomannan Helps Reduce Food Intake and Supports Long-Term Weight Loss in Mice on a High-Fat Diet

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