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Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA
How PER Protein Controls the Fruit Fly's Body Clock Both on and off DNA
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Abstract
In the Drosophila model, the circadian repressor PERIOD (PER) exhibits two mechanisms to inhibit CLOCK/CYCLE (CLK/CYC)-mediated transcription.
- PER is recruited to circadian promoters, leading to a decrease in CLK/CYC activity at night.
- The reduction in CLK/CYC activity is proportional to the amount of PER bound to DNA.
- CLK is released from DNA and forms a strong off-DNA complex with PER in a roughly 1:1 ratio.
- Dynamic changes in PER levels bound to CLK are crucial for transcriptional repression.
- These mechanisms may involve processes that occur before post-translational events and could also apply to mammals.
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