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Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances
Early and late wake therapy improve mood differently in pregnancy and after birth by changing melatonin and sleep timing
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Abstract
Early-night wake therapy (EWT) improved mood more in antepartum depressed patients compared to postpartum patients.
- EWT was associated with reduced melatonin-sleep phase-angle differences due to delayed melatonin onsets and advanced sleep onsets.
- Total sleep time increased from baseline for antepartum depressed patients receiving EWT.
- Late-night wake therapy (LWT) improved mood more in postpartum depressed patients compared to antepartum patients.
- LWT was linked to an increase in total sleep time for postpartum depressed patients.
- The findings suggest that tailoring sleep/wake interventions to specific peripartum conditions may optimize mood benefits.
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