Late, but not early, wake therapy reduces morning plasma melatonin: Relationship to mood in Premenstrual Dysphoric Disorder

Melatonin offset was delayed and duration was longer in women with Premenstrual Dysphoric Disorder (PMDD) compared to normal controls during the late luteal phase.

• Wake therapy, specifically late wake therapy (LWT), advanced melatonin offset and shortened melatonin duration compared to baseline levels in PMDD patients.
• Both LWT and early wake therapy (EWT) improved mood similarly in PMDD, despite differences in melatonin secretion patterns.
• Increased melatonin duration during the mid-follicular phase was associated with greater mood improvement after LWT in PMDD patients.
• Later morning melatonin offset was linked to more severe depressive symptoms in PMDD patients.

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