Eating meals before wheel-running exercise attenuate high fat diet-driven obesity in mice under two meals per day schedule

Mice that exercised after meals gained less body weight and visceral fat compared to those that exercised before meals.

• Feeding before exercise in the morning and evening resulted in greater reduction of weight gain from a high-fat diet compared to other feeding and exercise combinations.
• There were no significant differences in total food intake or total exercise wheel counts across different groups.
• Morning exercise was associated with increased activity levels, as indicated by higher wheel counts in groups that exercised after feeding.
• Positive correlations were found between muscle volumes and morning exercise, while negative correlations were observed between morning food intake and body weight.
• Evening exercise was linked to reduced fat volume increases, suggesting a potential benefit for countering fat deposition.

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