Voluntary wheel running reduces weight gain in mice by decreasing high-fat food consumption

Wheel running for 30 minutes on 5 days each week reduced weight gain and fat mass in mice fed a high-fat diet.

• Mice given access to a running wheel showed reduced weight gain and fat mass compared to those without access.
• High-fat food consumption decreased in mice that exercised, while standard chow intake remained unchanged.
• Mice with a locked running wheel, but fed the same amount of food as exercising mice, also experienced reduced weight gain and fat mass.
• The findings suggest that exercise may lead to weight management by lowering high-fat food intake.

AI simplified