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Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial
How General and Regional Anesthesia Affect Melatonin Rhythms and Their Link to Post-Surgery Confusion in Older Hip Fracture Patients
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Abstract
A total of 138 patients will be enrolled to compare melatonin secretion rhythms following general and regional anaesthesia.
- (POD) occurs frequently after hip fracture surgery and is linked to increased risks in elderly patients.
- disruptions may play a role in the development of POD.
- Previous studies have provided limited data on plasma melatonin levels post-surgery, failing to capture a complete melatonin rhythm.
- The impact of general anaesthesia versus regional anaesthesia on melatonin rhythms post-surgery remains unclear.
- It is hypothesized that regional anaesthesia may reduce melatonin rhythm disruption and potentially lower POD incidence.
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Key numbers
138
Patient Count
Total number of patients scheduled for hip fracture surgery
69 of 138
Group Size
Number of patients in each anaesthesia group (GA and RA)