Liposomal bupivacaine in pre-surgery nerve block and its effects on pain and delirium after hip fracture surgery in older patients

The occurrence of postoperative delirium (POD) will be evaluated in a randomized clinical study involving liposomal bupivacaine and ropivacaine for hip fracture surgery.

• Postoperative delirium is the most common acute mental state change after hip fractures in older adults.
• Postoperative pain is identified as a Grade A risk factor for the development of POD.
• The fascia iliac block may effectively reduce the incidence of POD in patients undergoing hip fracture surgery.
• Liposomal bupivacaine has a long half-life and may decrease opioid consumption, potentially improving patient recovery.
• The study aims to clarify whether regional nerve block analgesia can reduce POD occurrences in elderly patients.

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