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Efficacy and Safety of Liraglutide and Semaglutide on Weight Loss in People with Obesity or Overweight: A Systematic Review
Effectiveness and Safety of Liraglutide and Semaglutide for Weight Loss in Overweight or Obese People
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Abstract
Semaglutide 2.4 mg resulted in an average weight loss of -12.47 kg in individuals with obesity or overweight.
- Semaglutide 2.4 mg demonstrated the highest weight loss compared to liraglutide 3.0 mg (-5.24 kg), semaglutide 1.0 mg (-3.74 kg), and liraglutide 1.8 mg (-3.29 kg).
- All treatments were more effective than placebo in reducing HbA1c levels, with semaglutide 2.4 mg showing the greatest reduction (MD=-1.48%).
- The incidence of total adverse events was highest for semaglutide 2.4 mg, followed by liraglutide 3.0 mg, liraglutide 1.8 mg, and semaglutide 1.0 mg.
- Serious adverse events were most frequently associated with liraglutide 3.0 mg, followed by liraglutide 1.8 mg, semaglutide 2.4 mg, and semaglutide 1.0 mg.
- Hypoglycemic events were more common with semaglutide 2.4 mg than with liraglutide 3.0 mg, semaglutide 1.0 mg, and liraglutide 1.8 mg.
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Key numbers
-12.47 kg
Weight Loss (kg)
Weight loss compared to placebo.
-1.48%
HbA1c Reduction (%)
Reduction compared to placebo.
2.36
Total Adverse Events Ratio
Odds ratio for total adverse events.