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Abstract
Ellagic acid (EA) induces the trans-differentiation of white adipocytes to beige adipocytes in cold-exposed mice.
- EA promotes the expression of several key factors associated with brown and beige adipose tissue, including UCP1, PRDM16, and PGC1α.
- Mitochondrial dynamics-related factors such as SIRT3 and DRP1 are also increased by EA treatment.
- The browning effect of EA is inhibited by a DRP1 inhibitor, indicating its role in this process.
- SIRT3 knockdown reduces the impact of EA, suggesting its involvement in the beige remodeling of white adipose tissue.
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