Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning

Mar 9, 2017Diabetes

Id1 May Promote Obesity by Reducing Heat Production in Fat and Preventing Fat Cells from Becoming Heat-Producing

AI simplified

GLP-1 Therapies on OpenScience ↗PubMed ↗DOI ↗

Abstract

Adipose tissue-specific overexpression of Id1 causes age-associated and high-fat diet-induced obesity in mice.

Id1 suppresses thermogenesis in brown adipose tissue by inhibiting the activity of PGC1α.
In white adipose tissue, Id1 is primarily found in the stromal vascular fraction, where progenitor cells are located.
The absence of Id1 leads to increased expression of beige adipocyte genes and Ucp1 when exposed to cold.
Brown-like differentiation is enhanced in Id1-deficient mouse embryonic fibroblasts.
Id1 interacts with and inhibits Ebf2, reducing the expression of Prdm16, which is crucial for beige/brown adipocyte development.

AI simplified

Obesity results from increased energy intake or defects in energy expenditure. Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) controls BAT-mediated thermogenesis by regulating the expression ofInhibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays an important role in cell proliferation and differentiation. We demonstrate a novel function of Id1 in BAT thermogenesis and programming of beige adipocytes in white adipose tissue (WAT). We found that adipose tissue-specific overexpression ofcauses age-associated and high-fat diet-induced obesity in mice. Id1 suppresses BAT thermogenesis by binding to and suppressing PGC1α transcriptional activity. In WAT, Id1 is mainly localized in the stromal vascular fraction, where the adipose progenitor/precursors reside. Lack of Id1 increases beige gene and Ucp1 expression in the WAT in response to cold exposure. Furthermore, brown-like differentiation is increased in-deficient mouse embryonic fibroblasts. At the molecular level, Id1 directly interacts with and suppresses Ebf2 transcriptional activity, leading to reduced expression of, which determines beige/brown adipocyte cell fate. Overall, the study highlights the existence of novel regulatory mechanisms between Id1/PGC1α and Id1/Ebf2 in controlling brown fat metabolism, which has significant implications in the treatment of obesity and its associated diseases, such as diabetes. Ucp1Id1Id1Prdm16

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text ↗View full text (PDF) ↗

Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief