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Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional status
Elovl3 as a key gene linking the body’s day-night cycle and nutritional state
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Abstract
The ELOVL3 protein's gene expression is influenced by circadian rhythms and nutritional status.
- Circadian expression of the Elovl3 gene is disrupted in mutant CLOCK mice but remains present in those with severe liver dysfunction.
- The expression of Elovl3 shows a distinct sexually dimorphic pattern.
- RevErbalpha represses and SREBP1 activates the upstream region of the Elovl3 gene.
- Proteolytic activation of SREBP1 follows a circadian rhythm in the liver.
- Meal timing affects the activation cycle of SREBP1, potentially allowing it to respond rapidly to nutritional changes.
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