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Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control
Natural GLP-1 Receptor Signals in the Brainstem Area Help Control Food Intake
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Abstract
Chow intake and meal size were significantly increased following chronic knockdown of GLP-1 receptors in the hindbrain.
- Chronic knockdown of GLP-1 receptors in the nucleus tractus solitarius (NTS) results in increased food consumption.
- Self-administration of palatable food was significantly higher following NTS GLP-1 receptor knockdown under both fixed and progressive schedules.
- Endogenous GLP-1 receptor signaling in the NTS is associated with the regulation of food intake.
- The findings suggest distinct populations of GLP-1 receptors may play critical roles in various functions related to energy balance.
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