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Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation
Cell signals involved in how activating a hindbrain receptor reduces food intake
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Abstract
Hindbrain activation of glucagon-like peptide-1 receptors (GLP-1R) suppresses food intake and body weight through coordinated signaling pathways.
- Activation of GLP-1R by Exendin-4 increased PKA and MAPK activity while decreasing AMPK phosphorylation in the nucleus tractus solitarius.
- Inhibition of PKA and MAPK signaling reduced the effects of GLP-1R activation on food intake and body weight.
- The suppression of feeding was associated with a reduction in meal number rather than meal size.
- Stimulation of AMPK activity diminished the food intake suppression caused by GLP-1R activation.
- The signaling responses to GLP-1R activation were also observed in GLP-1R-expressing neurons.
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