Endogenous Rhythms inPeriod1Mutant Suprachiasmatic NucleiIn VitroDo Not Represent Circadian Behavior

Nov 20, 2009The Journal of neuroscience : the official journal of the Society for Neuroscience

Internal rhythms in mutant brain clock tissue studied outside the body do not match daily behavior patterns

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Abstract

Aberrant rhythms in ex vivo suprachiasmatic nuclei (SCN) lacking functional Period1 (Per1(-/-)) do not match the behavioral rhythms of the mutant animals.

  • Lesions of the SCN disrupt normal locomotor activity rhythms.
  • Fetal SCN tissue transplants can restore rhythmic behavior aligned with the donor's genotype.
  • In Per1(-/-) mice, the real-time circadian gene promoter activity rhythm is weak or absent in adult SCN slices.
  • Despite the absence of strong circadian rhythms in the SCN, wheel-running activity rhythms in Per1(-/-) mice are similar to wild-type.
  • Some neurons in the Per1(-/-) SCN show robust circadian rhythms, while others exhibit irregular or low-amplitude rhythms.
  • Findings suggest that either a small group of rhythmic neurons or in vivo physiological factors may compensate for the irregular rhythms in Per1(-/-) SCN.

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